I own a pair of the 225's that I have been using for the last three years. If you have any specific questions send me a pm or post here.
As for my general personal experience, I have mostly fanboy advice to offer. Without too much audiophile garble to go into; these are my go-to listening device for personal interaction with music. After discovering a new music set I like, I often can't wait to "listen to this with my Grados without distraction".
Clean, Open, and Accurate, are the three words I would associate with the cans. The sound approximates the breath of speaker system well for headphones in that it doesn't feel like a closed environment. To me, this is the main draw. The sound also seems accurate, which can be a blessing or a curse depending on the source material. I've had great listening experiences with both lossy and lossless music with these headphones, though the limitations of the recording environment/post-production are always apparent in both their glory and shortcomings.
What I always want more from these cans is bass. From my personal reference, you'll be able to hear every finger scrape Phil plays on early 70s recordings, but none of them will jar the fillings out of your teeth. Same with Mike; every note will be represented beautifully, but none will rattle your skull like a full sound system or a set of phones more colored for bass.
Different listening environments are useful for different experiences. These cans are my go-to for careful listening with headphones attached.
These headphones also improve with age. It took me approximately 50-75 hours of play to dampen the brightness of the highs and mids. I let them play overnight a few nights before giving the sound a final chance. Seems to get better, but subjectivity is a bitch.
Did I mention they are hand assembled in the USA?